Small-Pox in Mexico.

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B. F. Gentry to W. R. Gentry (12 July 186?)

Benjamin discussing food, general conditions and their movements around northern Mississippi, near Tupelo, Ripley and Saltillo.https://egrove.olemiss.edu/ciwar_corresp/1382/thumbnail.jp

The Personal Responsibility Pandemic: Centering Solidarity in Public Health and Employment Law

Our nation’s response to the coronavirus pandemic has revealed fundamental flaws in our legal regimes governing both public health and employment. Public health orders have called on individuals to make sacrifices to protect society as a whole. Simple fairness dictates that the burdens should be shared as widely as the benefits. And the case for burden-sharing does not rest on fairness alone. Public health measures are more likely to succeed when those who are subject to them understand them as fair1 and when their cooperation is supported. 2 Predictably, our pandemic response has placed disproportionate burdens on those who are already disadvantaged due to economic, racial, gender, disability, immigration, and criminal injustice.3 Elected officials have asked each of us to take personal responsibility for weathering this crisis rather than providing community supports and legal protections that would cushion the blow, spread the costs more widely, and enable everyone to abide by and benefit from public health recommendations

Apollo experience report: Development of guidance targeting techniques for the command module and launch vehicle

The development of the guidance targeting techniques for the Apollo command module and launch vehicle is discussed for four types of maneuvers: (1) translunar injection, (2) translunar midcourse, (3) lunar orbit insertion, and (4) return to earth. The development of real-time targeting programs for these maneuvers and the targeting procedures represented are discussed. The material is intended to convey historically the development of the targeting techniques required to meet the defined target objectives and to illustrate the solutions to problems encountered during that development

B. F. Gentry to W. R. and Mariah Gentry (22 August 1863)

Benjamin discusses food quality and requests money to buy supplies. Also passes along word to his family and servants.https://egrove.olemiss.edu/ciwar_corresp/1378/thumbnail.jp

B. F. Gentry to W. R. and Mariah Gentry (29 October 1862)

Benjamin discussing hearing of other battles, his marching in poor weather and word from home. Also provides a list of desired clothing from his mother.https://egrove.olemiss.edu/ciwar_corresp/1379/thumbnail.jp

B. F. Gentry to W. R. and Mariah Gentry (April 1864)

Benjamin mentions rumors of fighting in Chattanooga, TN., and speculates on Virginia and North Carolina; mentions his regiment\u27s movements and discusses hearing of life at home.https://egrove.olemiss.edu/ciwar_corresp/1381/thumbnail.jp

Facilitation of Neuropathic Pain by the NPY Y1 Receptor-Expressing Subpopulation of Excitatory Interneurons in the Dorsal Horn

Endogenous neuropeptide Y (NPY) exerts long-lasting spinal inhibitory control of neuropathic pain, but its mechanism of action is complicated by the expression of its receptors at multiple sites in the dorsal horn: NPY Y1 receptors (Y1Rs) on post-synaptic neurons and both Y1Rs and Y2Rs at the central terminals of primary afferents. We found that Y1R-expressing spinal neurons contain multiple markers of excitatory but not inhibitory interneurons in the rat superficial dorsal horn. To test the relevance of this spinal population to the development and/or maintenance of acute and neuropathic pain, we selectively ablated Y1R-expressing interneurons with intrathecal administration of an NPY-conjugated saporin ribosomal neurotoxin that spares the central terminals of primary afferents. NPY-saporin decreased spinal Y1R immunoreactivity but did not change the primary afferent terminal markers isolectin B4 or calcitonin-gene-related peptide immunoreactivity. In the spared nerve injury (SNI) model of neuropathic pain, NPY-saporin decreased mechanical and cold hypersensitivity, but disrupted neither normal mechanical or thermal thresholds, motor coordination, nor locomotor activity. We conclude that Y1R-expressing excitatory dorsal horn interneurons facilitate neuropathic pain hypersensitivity. Furthermore, this neuronal population remains sensitive to intrathecal NPY after nerve injury. This neuroanatomical and behavioral characterization of Y1R-expressing excitatory interneurons provides compelling evidence for the development of spinally-directed Y1R agonists to reduce chronic neuropathic pain